Immuno-Oncology Translational Network (IOTN)

IOTN Awardees

U01/UG3 IMMUNOPREVENTION PROJECTS

UG3CA244697
Intercepting Progression from Pre-invasive to Invasive Lung Adenocarcinoma
Weill Medical College of Cornell University Altorki, Nasser Khaled Borczuk, Alain
Elemento, Olivier
Mcgraw, Timothy
Mittal, Vivek
U01CA233097
Epithelium-Derived Alarmins Role in Breast Cancer Immunoprevention
Massachusetts General Hospital Demehri, Shadmehr
UG3CA244687
Recurrent Tumor-specific Alternately Processed Transcripts as a Source of Neoantigens for NF1-associated Malignant Peripheral Nerve Sheath Tumor Immunoprevention
University of Minnesota Largaespada, David
U01DE029255
Robust Immuno-prevention Strategies for High-risk Oral Epithelial Dysplasia
University of Michigan Lei, Yu Leo Brenner, John Chadwick
Neamati, Nouri
U01CA233056
Neoantigen Vaccination for Lynch Syndrome Immunoprevention
Weill Medical College of Cornell University
MD Anderson Cancer Center Lipkin, Steven Vilar-Sanchez, Eduardo



U01 IMMUNOTHERAPY PROJECTS

U01CA244452
Mechanisms of Exosome Driven Immunoregulation of Cancer Progression
University of California, San Francisco Blelloch, Robert Fong, Lawrence
U01CA239258
Enhancing Cell Therapy for Brain Tumors
Children's Research Institute
Johns Hopkins University
University of North Carolina at Chapel Hill Bollard, Catherine Cruz, Conrad Russell
Jones, Richard
Savoldo, Barbara
U01CA233096
Cytokine Immunotherapies for Melanoma
Yale University Bosenberg, Marcus Ring, Aaron





U01CA232758
B Cell-Dependent Anti-Tumor Immunity in Ovarian Cancer
Duke University Conejo-Garcia, Jose
U01CA233078
N-Glycosylation and Immunotherapy for Cancer
University of California, Irvine Demetriou, Michael
U01CA244314
Human CD3epsilon Co-potentiation to Boost Immunotherapy
University of Missouri-Columbia Gil Pagés, Diana
U01CA244291
Optimizing Myeloma-specific Immunity After Autologous Stem Cell Transplantation
Fred Hutchinson Cancer Research Center Hill, Geoffrey
U01AA027681
Immunosuppressive Mechanisms Responsible for Development of Non-Viral Liver Cancer and Control of its Response to Immune Checkpoint Inhibitors
University of California, San Diego
University of Southern California
MD Anderson Cancer Center Karin, Michael El-Khoueiry, Anthony
Shalapour, Shabnam
Tsukamoto, Hidekazu
U01CA233084
MUC1-C is a Target for Reversing Immune Evasion and Resistance to Immunotherapies
Dana-Farber Cancer Institute
New York University Kufe, Donald Wong, Kwok Kin
U01CA233102
Immunomodulation of the Tumor Microenvironment with Molecular Targeted Radiotherapy to Facilitate an Adaptive Anti-Tumor Immune Response to Combined Modality Immunotherapies
University of Wisconsin – Madison Morris, Zachary Weichert, Jamey
U01CA233085
Reprograming the Tumor Microenvironment to Overcome Multiple Primary and Acquired Immune Resistance Mechanisms in Ovarian Cancer
University of Chicago
University of Pittsburgh
Roswell Park Comprehensive Cancer Center Odunsi, Kunle Gambotto, Andrea
Kozbor, Danuta
U01DE028227
Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck Cancers
La Jolla Institute for Immunology
University of California, San Diego Schoenberger, Stephen Gutkind, J Silvio
Rao, Anjana
U01DE028233
Targeting the Immunosuppressive Tumor Microenvironment to Enhance Efficacy of Radiotherapy and Immuno-Radiotherapy for Oral Cancer
MD Anderson Cancer Center
Baylor College of Medicine Sikora, Andrew Annapragada, Ananth
U01DE029188
Defining Mechanisms of Immunotherapy Resistance in Head and Neck Squamous Cell Carcinomas
Dana-Farber Cancer Institute Uppaluri, Ravindra Barbie, David
Haddad, Robert
U01CA233100
Molecular and Immune Drivers of Immunotherapy Responsiveness in Prostate Cancer
Dana-Farber Cancer Institute
University of California, San Francisco Van Allen, Eliezer Fong, Lawrence
U01CA233074
Targeting Alternative Splicing for TCR Discovery in Small Cell Carcinomas
University of California, Los Angeles
Children's Hospital of Philadelphia Witte, Owen Crooks, Gay
Xing, Yi

U54 IMMUNOENGINEERING PROJECTS

U54CA244719
Nano-immuno-oncology Approaches to Overcome Tumor Immune Evasion
University of Texas Southwestern Medical Center Gao, Jinming Chen, Zhijian
Sumer, Baran
U54CA244711
Engineering the Next Generation of T Cells
University of Pennsylvania June, Carl Linette, Gerald
Milone, Michael
U54CA244438
UCSF Center for Synthetic Immunology: Tools to Reprogram the Immune System to Combat Cancer
University of California, San Francisco Lim, Wendell Desai, Tejal
Roybal, Kole
U54CA244726
Biomaterials to Create T Cell Immunity
Harvard University
Dana-Farber Cancer Institute Mooney, David Hodi, Frank
Scadden, David
Shih, William
Wu, Catherine

U01 Immune-Related Adverse Events Projects

U01CA247573
Engineering Immunotherapeutic Probiotics to Mitigate irAEs
Columbia University Danino, Tal
U01AI156189
Finding the Optimal Balance of Immunotherapy Efficacy and Toxicity
UT Southwestern Medical Center Gerber, David Wakeland, Edward
Xie, Yang
U01DK124165
Characterizing and Predicting Colitis in Immune Checkpoint Blockade-Treated Cancer Patients
Icahn School of Medicine at Mount Sinai Gnjatic, Sasha Colombel, Jean-Frederic
Faith, Jeremiah
U01AR077511
Identification of Pathways to Mitigate Immune-Related Adverse Events with Cancer Immunotherapy
National Jewish Health
Memorial Sloan Kettering Cancer Center Leung, Donald Kern, Jeffrey
Lacouture, Mario

U24 RESOURCE CENTERS

U24CA232979
IOTN: Data Management and Resource-Sharing Center
Roswell Park Comprehensive Cancer Center Hutson, Alan Liu, Song
Morgan, Martin
Odunsi, Kunle
U24CA233032
IOTN: Cellular Immunotherapy Data Resource (CIDR)
Medical College of Wisconsin Pasquini, Marcelo